Research & References
We think a supplement company should make it easy to read the science for yourself. Below are key peer-reviewed studies on Urolithin A, mitophagy and mitochondrial health that we reference across our site. We link to the original sources so you can read the full papers rather than take our word for it.
Note on interpretation: much of this research is early-stage, and some studies used doses different from ours. Studies of a compound are not proof of a health outcome for any individual. Mito Renewal Complete is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.
Human clinical studies
- Andreux PA, Blanco-Bose W, Ryu D, et al. “The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.” Nature Metabolism. 2019;1:595–603. Read on Nature Metabolism — first-in-human safety trial in healthy older adults.
- “Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.” JAMA Network Open. 2022;5(1). Read on JAMA Network Open — randomized trial in adults aged 65–90.
- Singh A, D’Amico D, Andreux PA, et al. “Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.” Cell Reports Medicine. 2022;3(5). Read on Cell Reports Medicine.
Foundational and preclinical research
- Ryu D, Mouchiroud L, Andreux PA, et al. “Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.” Nature Medicine. 2016;22:879–888. Read on Nature Medicine — the study that first characterised Urolithin A’s role in mitophagy.
To learn how Urolithin A relates to these processes in plain English, start with our beginner’s guide to Urolithin A.